Lodo Therapeutics Acquires Conifer Point Pharmaceuticals

  • Expands AI/ML Capabilities and Gains Exclusive Rights to Leading Suite of Cheminformatics Technologies
  • Conifer Point’s Technologies Enable Expansion of Lodo’s P4 PlatformTM to Include Therapeutic Target-Based De Novo Drug Discovery
  • Represents Major Advance in Lodo’s Reinvention of Natural Product Drug Discovery
  • Lodo to Present at 2020 Wedbush PacGrow Healthcare Virtual Conference

New York, NY – August 7, 2020 – Lodo Therapeutics Corp. (Lodo), a biotechnology company reinventing natural product drug discovery by applying its informatics-enabled technology platform to previously undruggable disease targets, today announced that it has completed the acquisition of Conifer Point Pharmaceuticals, LLC (Conifer Point). Conifer Point has proprietary tools and deep expertise in computational structural biology and cheminformatics. Lodo will integrate Conifer Point’s technology and know-how to enhance its artificial intelligence/machine learning (AI/ML) capabilities and expand its P4 PlatformTM for the in-silico discovery of novel drug leads from biosynthetic gene clusters (BGCs) in microbial DNA.

Dale Pfost, PhD, Chairman and CEO of Lodo, noted, “This is the first of our targeted strategic acquisitions designed to accelerate Lodo’s goal of reinventing natural product drug discovery. Conifer Point and its predecessor company, BioLeap, have pioneered the application of advanced cheminformatics and structural biology to drug discovery. Its molecular modeling technologies and algorithms have been tested and refined for more than a decade in real-world use with biopharmaceutical partners. Lodo’s initiative to adapt these capabilities to the domain of biosynthetically-produced molecules is a breakthrough that for the first time makes the possibility of de novo natural product drug discovery a reality.”

Dr. Pfost continued, “Our existing P4 Platform allows Lodo to access the vast chemical space of drug-like molecules encoded in microbial DNA starting from known, data-supported drug scaffolds, thereby unlocking a rich new source of lead candidates and analogs. The addition of Conifer Point’s technology allows de novo discovery starting from a disease target of interest, rather than a known drug scaffold. This makes it possible for Lodo to discover, enrich and prioritize large numbers of biologically and pathway-relevant molecules addressing hard-to-drug disease targets in silico, with unprecedented gains in predictive power and significantly enhanced efficiency.”

Conifer Point’s integrated cheminformatic and structural biology modeling platform creates an in-silico map of where, and with what relative affinity, molecules and their fragments bind to target proteins. The technology includes a variety of advanced tools and software for assessing the engagement of natural product molecules and their docking to targets of interest, greatly facilitating the ability of drug researchers to enumerate, select and prioritize potential leads in silico.

The company’s proprietary tools include the Grand Canonical Monte Carlo Fragment Simulator for generating chemical fragment binding maps. It is among the industry’s highest performing protein-fragment simulation software in terms of speed and accuracy and is the only platform with the demonstrated ability to produce hundreds of thousands of accurate binding maps on an industrial scale. Associated software incorporates 3D molecular visualization and extensive capabilities for managing and searching the very large binding data sets produced by the Simulator.

Lodo will house Conifer Point’s technology at its New York City-based facilities. John Kulp Jr., PhD, Chief Technology Officer at Conifer Point and an inventor of its technology, is joining Lodo as Vice President, Cheminformatics. Conifer Point founder and CEO, John Kulp lll, PhD, will serve as a consultant to Lodo.

Dr. John Kulp, lll commented, “The sophisticated drug discovery tools and technologies first developed at BioLeap and advanced by Conifer Point have demonstrated their utility for improving drug discovery efficiency and effectiveness across chemical classes and therapeutic areas. We are delighted to join forces with Lodo, whose commitment to applying informatics, genomics and synthetic biology to reinvent natural product drug discovery is fully aligned with our vision. We see Lodo as well situated to extend the full potential of our unique technology to the domain of natural product therapeutics. I look forward to serving as a consultant to help the Lodo team make optimal use of these powerful tools.”

Dr. John Kulp, Jr. has decades of experience developing and applying AI/ML and other advanced computational technologies to biopharmaceutical uses. At the Sarnoff Corporation (now Stanford Research International), Dr. Kulp established the large-scale biophysical simulation team and served as Vice President. At Sarnoff he helped form Locus Pharmaceuticals before founding BioLeap, a leader in computational fragment-based molecular design. Dr. Kulp served as founding CEO of BioLeap and was directly involved in the coding and application of BioLeap’s Grand Canonical Monte Carlo simulation program with pharmaceutical and biotechnology company partners. Its assets were acquired by Conifer Point in 2015. Dr. Kulp earned BS and MS degrees in Electrical Engineering and Computer Science and a PhD in Electrical Science from the Massachusetts Institute of Technology.

Further financial details were not disclosed.

Separately, Lodo announced that Dale Pfost will present at the 2020 Wedbush PacGrow Healthcare Virtual Conference on Wednesday, August 12, 2020 at 8:35 am ET. A live webcast of the presentation will be available at http://wsw.com/webcast/wedbush36/lodo/2229562. A replay of the webcast will be available for 90 days following the presentation.

About Lodo Therapeutics
Lodo is reinventing natural product drug discovery with its technology enabled P4 PlatformTM and ClusterTechTM suite of informatics tools. Our DNA-first approach taps the structurally diverse, biologically relevant drug-like molecules encoded in microbial DNA. Lodo integrates breakthroughs in next-generation sequencing, artificial intelligence/machine learning and synthetic biology to identify, characterize and prioritize lead molecules in silico. Lodo uses synthetic biology to boost production and enhance candidate molecules’ pharmacologic properties, including their ability to engage challenging targets. Together, these integrated technologies increase the scalability, efficiency and productivity of the discovery process by orders of magnitude. We view our ability to efficiently access, annotate and prioritize large numbers of natural product drug-like molecules in silico as a historic breakthrough. Following successful initial collaborations with two leading global partners, Lodo is developing a pipeline of oncology drugs and seeking additional partners in a range of indications. Lodo is headquartered in New York City and is supported by top tier investors, including Arch Venture Partners, Alexandria Venture Investments, Pfizer, AbbVie and Lilly. For more information, visit lodotherapeutics.com.

Contact:

Lodo Therapeutics

Barbara Lindheim
Strategic Communications & Investor Relations
blindheim@lodotherapeutics.com
(917) 355-9234


Lodo Therapeutics Names Serial Biotech Entrepreneur Dale Pfost as CEO and Adds Top Industry Veterans to Leadership Team

  • Lodo’s Unique Platform Integrates Next-Generation Sequencing, AI/ML and Synthetic Biology to Reinvent Environmentally-Sourced, Natural Product Drug Discovery
  • This Platform Allows Lodo to Identify and Prioritize Novel Drug Leads Directly from the Millions of Undiscovered Molecules Encoded in Environmental Microbial DNA
  • Validation of Platform in Projects with Global Partners Sets the Stage for Expanded Industry Collaborations and Advancement of Lodo’s Internal Pipeline

New York, NY – December 20, 2019 – Lodo Therapeutics Corp., a biotechnology company applying its proprietary platform to reinvent environmentally-sourced, natural product drug discovery, today announced the appointment of Dale Pfost, PhD, as Chairman and Chief Executive Officer. Dr. Pfost has more than 25 years of experience as a life science entrepreneur, senior executive and venture investor. He has served as CEO of five biotechnology companies, three of which became publicly traded with valuations exceeding two billion dollars. Dr. Pfost has successfully completed dozens of financings, overseen numerous M&A transactions and served as a director at multiple public and private life science firms.

The company also announced the addition of four members to the senior leadership team: Steve Colletti, PhD, Senior Vice President of R&D; Anthony Colasin, Senior Vice President of Business Development; Barbara Lindheim, Consulting Vice President of Strategic Communications and Investor Relations; and Sarajane Mackenzie, Consulting Vice President of Human Resources and Organization Development.

Accelerator Life Science Partners’ chief executive, Thong Q. Le, served as Lodo’s initial CEO and remains a Lodo director. Mr. Le noted, “Lodo is one of the shining stars of our New York City-based portfolio companies. It is leveraging the pioneering metagenomic research of Dr. Sean Brady at Rockefeller University to tackle a big challenge—revolutionizing the field of environmentally-sourced, natural product drug discovery. Lodo has demonstrated that its technology-enabled platform can identify wholly novel molecules directly from environmental DNA with the potential to address currently undruggable targets. Dale brings Lodo a wealth of experience in growing cutting-edge enterprises and is supported by the expert scientific and business talent joining the Lodo team. We are thrilled he is taking the reins at this exciting time in the company’s development.”

Lodo’s technology reinvents and reinvigorates environmentally-sourced, natural product drug discovery. The company’s platform uniquely integrates next-generation sequencing (NGS), artificial intelligence/machine learning (AI/ML), synthetic biology and automation to access undiscovered molecules directly from biosynthetic gene clusters encoded in the microbial DNA present throughout nature. The molecules produced by these microbes exhibit extensive chemical diversity and are biologically relevant. Honed by a billion years of evolution, their functions and activities include signaling, regulating growth, immunomodulation, antiproliferative, and modulating intra and intercellular interactions. The Lodo platform is designed to capture data on these functions at the level of the encoded DNA, thereby obviating the need to first culture the microbe and assay the metabolites. This greatly accelerates the discovery process while significantly decreasing costs.

Pharmaceuticals derived from natural sources, while representing more than half of the most widely used drugs, were developed from the tiny fraction of microbes that can be readily cultured in the laboratory (estimated at less than 1%). By extracting, analyzing and prioritizing microbial DNA directly from the environment, Lodo is able to efficiently access an entire universe of chemically diverse, drug-like compounds created by this microbial treasure trove, and it does so initially using DNA data, prior to working with the compounds themselves.

Lodo is applying its platform to discover novel anti-infective agents for two global partners while building an internal pipeline of oncology drug candidates. The company expects to establish additional partnerships and expand its own programs in other therapeutic areas.

Dr. Pfost commented, “Pharmaceuticals derived from nature have been among the richest sources of important drugs. But productivity declined as the limitations and costs of conventional technology restricted researchers to a small pool of candidates. Lodo’s platform is a game changer. It uniquely integrates advanced technologies including NGS and AI/ML to leapfrog those limitations, providing us a historic opportunity to reinvent environmentally-sourced drug discovery.”

Dr. Pfost continued, “We are the only company that can broadly access microbial DNA encoding such highly diverse collections of drug-like molecules, and we can also analyze, prioritize and enrich these molecules in silico, with orders of magnitude improvements in efficiency and speed. Our scientists combine deep knowledge of molecular and biological targets with computer-aided structure activity relationship data to bridge from the DNA to assessments of the encoded molecule’s ability to bind to its target. This represents a quantum leap in capability compared to the laborious and costly laboratory methods required for conventional natural product drug research. I welcome the opportunity to work with our exceptional team, top-tier partners and investors to further advance our platform and address major unmet medical needs.”

Lodo director Steven Gillis, PhD, is a Managing Director of Arch Venture Partners and a renowned biotechnology inventor, entrepreneur and investor. Dr. Gillis said, “Dale Pfost and the newly appointed senior team are an excellent choice to lead Lodo, which has developed a unique platform incorporating advances in both life sciences tools and computational technologies. It enables researchers for the first time to rapidly and efficiently access the 99% of undiscovered microbial DNA-encoded molecules that may have potential as novel drugs. This promising approach could help reinvigorate the lagging productivity of conventional drug discovery and produce innovative medicines for several diseases that remain poorly treated.”

Dr. Pfost previously was General Partner at venture capital firm Advent Life Sciences and acting CEO of MicroBiome Therapeutics, which he co-founded. Dr. Pfost was founding CEO of Acuity Pharmaceuticals, which merged to form OPKO Health. He was the founding CEO of Oxford GlycoSciences and genomics pioneer Orchid BioSciences. Dr. Pfost was CEO at anti-cancer company Receptor BioLogix, where he led its successful acquisition by Symphogen. His first company, which he started in graduate school, was acquired by SmithKline Beckman and produced the Biomek, still a leading laboratory automation system today. Dr. Pfost is the co-author of 10 scientific papers and an inventor on 10 patents. He earned a BS degree from the University of California Santa Barbara and a PhD in physics from Brown University.

Dr. Colletti brings 24 years of experience at Merck Research Laboratories in small molecule, natural products, RNA therapeutic and fusion protein drugs. Starting as a medicinal chemist, Dr. Colletti assumed positions of increasing responsibility at Merck. Most recently, he was Executive Director and Head of Therapeutic Modalities, responsible for overseeing 200 scientists. Dr. Colletti was a core member of development teams that discovered and advanced more than a dozen preclinical candidates across multiple therapeutic areas. He is an inventor, author and co-author of over 125 publications and patents. Dr. Colletti completed a BS degree at Loyola University Chicago, received a PhD in chemistry from Boston University, and was an NIH Postdoctoral Research Fellow in chemistry at the Scripps Research Institute.

Anthony Colasin has over 20 years of leadership experience in strategy and corporate and business development at large and emerging biotechnology firms. He has an extensive track record in creating and implementing business and partnering strategies, with deal transactions valued at more than $3 billion. Mr. Colasin most recently co-founded microbiome-based drug developer Bloom Science. Previously, he was the Chief Business Officer for neurological drug developer Bionomics and Vice President of Business Development for Ironwood Pharmaceuticals. Mr. Colasin began his career at Amgen and ICOS. He has an MBA from the Anderson School at the University of California, Los Angeles and a BS degree in economics magna cum laude from the University of Southern California, and also served in the U.S. Marine Corps.

Barbara Lindheim provides strategic communications services to the biotechnology and life sciences industries. Her more than 25 years of experience spans public relations, strategic positioning, corporate and product communications, investor relations, crisis communications and social media. She is a Principal at BLL Partners, LLC, and previously held senior communications, marketing and strategy roles at Orchid BioSciences, Edelman Public Relations, BioCom Partners, Noonan/Russo Communications, Glaxo SmithKline, Pfizer and Sanofi. An honors graduate of Cornell University, Ms. Lindheim earned an MBA with Distinction from Harvard Business School and a master’s degree in public policy from Princeton University. She lectures on biomedical industry strategy at leading business schools.

Sarajane Mackenzie has over 25 years’ global and cross-cultural experience in executive human resource positions in the biotech, pharmaceutical, consumer healthcare and information technology industries. She headed the human resource function at Novo Nordisk, Orchid Biosciences, Johnson & Johnson and Tata Consultancy Services. Ms. Mackenzie has helped transform businesses and manage rapid expansions. She is also President of The Mackenzie Consulting Group, LLC, which provides interim HR executives and does HR executive search at small and emerging life science companies She holds an undergraduate degree inpsychology from the University of California at Santa Cruz and a master’s degree in organization development from the University of San Francisco.

About Lodo Therapeutics
Lodo discovers and develops novel therapeutics addressing undruggable targets by applying its proprietary platform to tap the vast collections of undiscovered molecules encoded in environmental microbial DNA. These evolutionarily optimized leads include structurally diverse molecules with drug-like properties that have been largely inaccessible until now. The Lodo platform leverages breakthroughs in next-generation sequencing, artificial intelligence/machine learning and synthetic biology to increase speed and efficiency by orders of magnitude. Following successful initial collaborations with two global partners, Lodo is developing an internal pipeline of oncology drugs and expanding its partnering activities in a range of indications. Lodo is an Accelerator Life Science Partners-backed entity headquartered in New York City. For more information, visit lodotherapeutics.com.

Contact:
Lodo Therapeutics
Barbara Lindheim
Strategic Communications & Investor Relations
blindheim@lodotherapeutics.com
(917) 355-9234


Magnolia Neurosciences Corporation Announces that its Subsidiary Receives $20 Million CPRIT Grant to Develop Novel Therapies to Treat Chemotherapy-Induced Neurological Conditions

NEW YORK, NY and HOUSTON, TX – August 27, 2018 – Magnolia Neurosciences Corporation (Magnolia) today announced that Korysso Therapeutics, Inc. (DBA: Magnolia Tejas Corporation), the company’s wholly owned, Houston-based subsidiary, has been awarded a $19.95 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to fund the development of a novel targeted therapy for the treatment of neurological conditions
caused by chemotherapy. Once the grant contract is consummated, CPRIT will fund the advancement of the company’s lead molecule through the completion of Phase 1 and into Phase 2a clinical development. The company expects to initiate a Phase 1 clinical trial in the second half of 2019.

Magnolia Tejas is developing a targeted therapy for these conditions, including chemotherapyinduced peripheral neuropathy (CIPN) and chemotherapy-induced cognitive dysfunction (CICD or chemo brain) based on discoveries made by scientists in The University of Texas MD Anderson Cancer Center’s (MD Anderson) Therapeutics Discovery division and the Neurodegeneration Consortium (NDC).

CIPN results from drug-induced damage to peripheral nerves, which results in pain, numbness and tingling in the hands and feet. It is estimated that in the United States alone there are two million people living with CIPN and there is no approved therapy for the condition. CICD, which affects more than 200,000 patients each year, is characterized by general cognitive and memory problems that can last for years.

“The neuropathy and neurocognitive challenges caused by chemotherapy not only decrease a patient’s quality of life, but also can prevent them from completing the optimal chemotherapy regimen, ultimately affecting survival,” said Philip Jones, Ph.D., vice president of Therapeutics Discovery at MD Anderson, co-author of the CPRIT grant and a scientific advisor to Magnolia Neurosciences. “New treatments that address the underlying cause of CIPN are urgently needed, and a targeted approach has the potential to address the specific biologic mechanisms that contribute to peripheral nerve damage. We greatly appreciate the support from CPRIT to fund this important project.”

“Focusing on CIPN will provide near-term proof of concept for Magnolia Neurosciences’ targeted approach to neuroprotection,” said Thong Q. Le, chief executive officer at Magnolia Neurosciences Corporation and Accelerator Life Science Partners. “Coming on the heels of our recently announced $31M Series A financing, this grant from CPRIT will accelerate our entry into the clinic to treat patients with these often-crippling consequences of chemotherapy.”

CPRIT provides funding through its academic research, prevention, and product development research programs. Programs made possible with CPRIT funding have reached all 254 counties of the state of Texas, brought more than 159 distinguished researchers to the state, advanced scientific and clinical knowledge, and provided more than four million life-saving education, training, prevention, and early detection services to Texans. To date, CPRIT has awarded $2.15 billion in grants for cancer research.

About Magnolia Neurosciences Corporation
Magnolia Neurosciences Corporation is a drug discovery and development company focused on the creation of a novel class of neuroprotective medicines. The company endeavors to make life-changing medicines for the benefit of patients and their families suffering from serious CNS diseases. The company was launched by a $31M Series A investment by Accelerator Life Science Partners in 2018 and was co-founded by world class researchers at The University of Texas MD Anderson Cancer Center. The company’s offices are located in the Alexandria Center for Life Science, New York City’s first and only premier life science campus. The company also has a wholly owned subsidiary, Magnolia Tejas Corporation, based in Houston, Texas that is focused on developing a novel therapy for chemotherapy-induced neurological conditions. For more information, please visit www.magnolianeurosciences.com.


Accelerator Life Science Partners Launches Magnolia Neurosciences Corporation with $31 Million Series A to Develop Targeted Neuroprotective Therapies

NEW YORK, NY – August 13, 2018 – Accelerator Life Science Partners (Accelerator), a leading life science investment and management firm, today announced that it has launched Magnolia Neurosciences Corporation, a company developing a new class of neuroprotective medicines. Co-founded by Accelerator and The University of Texas MD Anderson Cancer Center (MD Anderson), the company will further develop discoveries made by scientists in MD Anderson’s Therapeutics Discovery division and the Neurodegeneration Consortium (NDC).

Investors participating in the $31 Million Series A financing include AbbVie Ventures, Alexandria Venture Investments, ARCH Venture Partners, Eli Lilly and Company, Innovate NY Fund, Johnson & Johnson Innovation – JJDC, Inc., the Partnership Fund for New York City, Pfizer Ventures, Watson Fund, L.P., WuXi AppTec’s Corporate Venture Fund and 180 Degree Capital Corp.

Neurodegenerative diseases and neuronal injury affect nearly 20 million individuals in the United States alone, and their incidence is expected to increase as the population ages. During embryonic development, excess neurons are eliminated by a process called programmed cell death. Research indicates that this tightly controlled process becomes re-activated in critical brain regions in Alzheimer’s disease and other neurological conditions. Blocking specific components of this process preserves brain tissue and leads to enhanced memory in animal models, suggesting that drugs targeting these key steps could maintain neural function.

“There is a critical need to develop medicines that slow or stop neuronal loss in these patients, and a growing body of data suggests that inhibition of these specific pathways has the potential to preserve neuron viability across a variety of disease states and pathological conditions,” said Jim Ray, PhD, director of Neurodegeneration Consortium. “Magnolia Neurosciences is focused on developing potent and highly selective neuroprotective therapies that have compelling preclinical pharmacologic profiles and for which clinical proof of concept can be obtained rapidly in order to address significant unmet patient needs.”

“The potential market for neuroprotective therapies is large and underserved, and we believe that Magnolia Neurosciences has the technology, intellectual property and scientific expertise to become a leader in the field,” said Thong Q. Le, chief executive officer at Magnolia Neurosciences Corporation and Accelerator Life Science Partners. “In launching Magnolia Neurosciences, we are pleased to be a catalyst for innovation that could improve the care and outcomes for millions of patients.”

Magnolia Neuroscience is built upon the expertise of scientists at MD Anderson, one of the world’s most respected cancer centers focused on patient care, research, education and prevention. With a comprehensive approach to improving patient care, scientists from MD Anderson and the NDC are focused on developing life-saving transformational medicines for patients in need of neuroprotective therapies, including those with Alzheimer’s disease and cancer.

“This investment in Magnolia Neurosciences exemplifies Pfizer’s commitment to funding neuroscience innovation and supporting cutting-edge translational neuroscience research,” said Laszlo Kiss, executive director, Worldwide Research & Development and principal at Pfizer Ventures. “Our new focus on neuroscience investing is designed to support entrepreneurs who are deciphering the molecular basis of neurologic disorders, and we believe that Magnolia

Neurosciences has the technology and scientific foundation on which to build an exciting portfolio of neuroprotective medicines.”

About Magnolia Neurosciences Corporation
Magnolia Neurosciences Corporation is a drug discovery and development company focused on the creation of a novel class of neuroprotective medicines. The company was launched by a $31 million Series A investment by Accelerator Life Science Partners in 2018 and was co- founded by world-class researchers at The University of Texas MD Anderson Cancer Center. The company endeavors to make life-changing medicines for the benefit of patients and their families suffering from serious CNS diseases. The company’s offices are located in the Alexandria Center for Life Science, New York City’s first and only premier life science campus. For more information, please visit www.magnolianeurosciences.com.

About Accelerator Life Science Partners
Accelerator Life Science Partners catalyzes the development and commercialization of breakthrough biotechnology innovations. Accelerator is a trusted partner that provides the complete business, scientific and financial toolkit necessary for successfully establishing and operating an early-stage biotechnology company. Accelerator nurtures its companies across all stages and in all facets of development, setting them on a path that offers the greatest chance for long-term success. Among these key resources are committed investment capital, experienced start-up management, world-class scientific expertise and state-of-the-art laboratories and shared facilities.

The company is uniquely positioned to provide this unprecedented collection of capabilities and resources through its partnership with top-tier investors, seasoned executive managers and world-class research institutions. The value of these collective resources has been validated over more than a decade of successful investing in life science companies that are helping to shape the rapidly evolving future of medicine and healthcare. For more information, please visit www.acceleratorlsp.com.

Media Contacts:

Rathbun Communications
Julie Rathbun
julie@rathbuncomm.com

Accelerator Life Science Partners
Jessica Burback
jburback@acceleratorlsp.com
T: 206-234-6481


Accelerator Life Science Partners Broadens its Leadership Teams and Expands its Geographic Operations to San Diego and the Greater Los Angeles Area

  • Newly formed Operating Partners group and Clinical and Scientific Advisory Board to provide critical insights to support portfolio companies’ success and guide investment strategies
  • Additional facility expected to catalyze the growth of innovative life science companies in Southern California

SEATTLE and NEW YORK – May 15, 2018 — Accelerator Life Science Partners (Accelerator), a leading life science investment and management firm, today announced that it has expanded its operations into San Diego and the Greater Los Angeles area with the opening of a new office at The Alexandria at Torrey Pines in San Diego. The firm also announced the formation of its Operating Partners group and Clinical and Scientific Advisory Board (CSAB). These strategic growth initiatives will better enable Accelerator to fulfill its dual missions of providing unique and compelling opportunities to its investors and partnering with cutting-edge life science companies to help achieve their near-term milestones and long-term visions.

“Accelerator is committed to supporting innovation wherever it takes place and without geographic limitation,” said David M. Schubert, chief operating partner at Accelerator. “Opening an office in San Diego, our third market, positions us to meet the needs of leading innovators throughout the vibrant San Diego and emerging Greater Los Angeles life science ecosystems. We have also brought together an experienced group of Operating Partners to support our ongoing efforts to identify new investment areas and specific company-building opportunities.”

Accelerator’s Operating Partners will assist with the evaluation of new business opportunities, support current (and future) Accelerator portfolio companies and serve in a variety of operating and board roles. The Operating Partners include:

  • Andrew Howard, Ph.D. (New York City, NY)
  • Wendy S. Johnson (San Diego, CA)
  • David L. Pompliano, Ph.D. (New York City, NY)
  • Francisco D. Salva (Philadelphia, PA)
  • John T. Santini, Jr., Ph.D. (Minneapolis, MN)
  • David M. Schubert  (New York City, NY)
  • Christopher T oombs, Ph.D. (Seattle, WA)
  • Court R. Turner, J.D. (San Diego, CA)

“Having state-of-the-art laboratories and world-class scientific leadership will help set our portfolio companies on a path to long-term success,” said Kendall Mohler, Ph.D., chief development officer at Accelerator. “We are excited to welcome our CSAB members to the Accelerator team. Advancing a groundbreaking scientific idea into and through clinical development takes not only robust data; it also requires critical insights into preclinical research, clinical trial design and strategy and keen understanding of the product approval pathway. Our CSAB members have demonstrated expertise in these areas, and we believe they will be an important asset as we partner with today’s most cutting-edge entrepreneurs.”

Accelerator’s CSAB Members:

  • Lee E. Babiss, Ph.D.
  • John Latham, Ph.D.
  • George L. McLendon, Ph.D.
  • Kendall M. Mohler, Ph.D.
  • Gerald T. Nepom, M.D., Ph.D.
  • Homer L. Pearce, Ph.D.
  • Anil K. Singhal, Ph.D.
  • James Tobin, Ph.D.

Additional information about the members of Accelerator’s Operating Partners and CSAB is available at: www.acceleratorlsp.com/our-team/.

About Accelerator Life Science Partners
Accelerator Life Science Partners catalyzes the development and commercialization of breakthrough biotechnology innovations. Accelerator is a trusted partner that provides the complete business, scientific and financial toolkit necessary for successfully establishing and operating an early-stage biotechnology company. Accelerator nurtures its companies across all stages and in all facets of development, setting them on a path that offers the greatest chance for long-term success. Among these key resources are committed investment capital, experienced start-up management, world-class scientific expertise and state-of-the-art laboratories and shared facilities.

The company is uniquely positioned to provide this unprecedented collection of capabilities and resources through its partnership with top-tier investors, seasoned executive managers and world-class research institutions. The value of these collective resources has been validated over more than a decade of successful investing in life science companies that are helping to shape the rapidly evolving future of medicine and healthcare. For more information, please visit www.acceleratorlsp.com

 

Media Contacts:

Rathbun Communications
Julie Rathbun
julie@rathbuncomm.com

Accelerator Life Science Partners
Jessica Burback
jburback@acceleratorlsp.com
T: 206-234-6481


Lodo Therapeutics Corporation Forms Multi-Target Strategic Collaboration with Genentech

  • Collaboration provides Genentech with access to Lodo Therapeutics’ proprietary metagenomics-based natural products drug discovery platform
  • Lodo to receive up to $969 million in upfront fees and milestone payments

New York, NY – May 9, 2018 – Lodo Therapeutics Corporation, a drug discovery and development company focused on identifying and producing unique, bioactive natural products directly from the microbial DNA sequence information contained in soil, today announced that it has formed a strategic drug discovery collaboration with Genentech, a member of the Roche Group.

Under the terms of the agreement, Genentech will utilize Lodo Therapeutics’ proprietary genome mining and biosynthetic cluster assembly platform to identify novel molecules with therapeutic potential against multiple disease-related targets of interest to Genentech. Lodo will receive an undisclosed upfront payment and is eligible to receive research, development and commercialization milestone payments up to $969 million based on achievement of certain predetermined milestones. In addition, Lodo is eligible to receive tiered-royalties on sales of certain products resulting from the collaboration.

“Lodo Therapeutics’ proprietary drug discovery platform is a powerful engine for identifying novel compounds with important therapeutic potential,” said Thong Q. Le, chief executive officer at Lodo Therapeutics and Accelerator Life Science Partners. “We are incredibly excited to work with Genentech, and we look forward to demonstrating the power and utility of Lodo’s unique technology for the benefit of global human health.”

Compounds derived from natural products comprise a significant proportion of the small molecule drugs used to treat cancer, infections and chronic illnesses such as Type 2 diabetes. Rather than relying on culturing known strains of bacteria, Lodo Therapeutics’ genome-based approach leverages the power of microbial evolution to identify novel, naturally occurring compounds that have therapeutic potential in the treatment of cancer and drug-resistant bacterial infections. This approach is expected to reduce the time and cost of drug discovery.

“Our ability to enter into a strategic collaboration with one of the leaders in innovating wholly new classes of drugs just two years after Lodo Therapeutics was founded reflects the potential of our proprietary platform to be a valuable resource to advance their drug discovery initiatives,” said David Pompliano, Ph.D., co-founder and chief scientific officer of Lodo Therapeutics.

“We are excited to work with Genentech in their quest to discover novel, next-generation natural products derived from the microbiome of the soil using this innovative platform developed by Lodo,” said Sean Brady, Ph.D., co-founder of Lodo Therapeutics and Associate Professor at The Rockefeller University.

James Sabry, M.D., Ph.D., senior vice president and global head of Genentech Partnering, commented, “Genentech is committed to accessing innovative technologies and we are excited to collaborate with Lodo Therapeutics to apply their Metagenomics Technology Platform to potentially discover therapeutics for difficult drug targets.”

About Lodo Therapeutics
Lodo Therapeutics Corporation is a drug discovery and development company focused on the creation of novel therapeutics derived from nature that will impact patients around the world. The company was established to pursue the scientific vision of Dr. Sean Brady, head of The Rockefeller University’s Laboratory of Genetically Encoded Small Molecules. Lodo Therapeutics identifies and produces bioactive natural products directly from the microbial DNA sequence information contained in soil. Information encoded in bacterial genomes, not experimental serendipity, drives the company’s discovery of new medicines. Not constrained by traditional culture-based approaches to natural products drug discovery, Lodo Therapeutics has unlocked a vast trove of overlooked compounds evolutionarily selected for processes essential for life and with significant potential in the treatment of drug-resistant microbial infections and cancers

Lodo Therapeutics was formed by Accelerator Life Science Partners and is headquartered in New York City. The company’s lab and offices are located in the Alexandria Center for Life Science, New York City’s first and only premier life science campus.

 

Media Contact(s)

Rathbun Communications
Julie Rathbun
julie@rathbuncomm.com

Accelerator Life Science Partners
Jessica Burback
jburback@acceleratorlsp.com


Proniras Corporation Awarded Contract Worth Up to $89.5 Million from U.S. Biomedical Advanced Research and Development Authority to Develop Tezampanel as a Medical Countermeasure for Nerve Agent-Induced Seizures

SEATTLE, WA – April 27, 2018 – Proniras Corporation, an Accelerator Life Science Partners (Accelerator) portfolio company, today announced that it has been awarded a contract potentially worth $89.5 million from the U.S. Department of Health and Human Service’s Biomedical Advanced Research and Development Authority (BARDA) to develop tezampanel as a medical countermeasure for the treatment of nerve agent-induced seizures that are not stopped by current medications. Tezampanel (also known as LY-293,558) is a small molecule compound that previously had been evaluated in clinical trials as a potential therapy for acute migraine and other neurologic indications and has demonstrated an attractive safety and pharmacokinetic profile in more than 400 human subjects.

“As recent events have clearly demonstrated, the need for medical countermeasures that can effectively treat nerve agent exposure is sadly more than theoretical,” said Christopher Toombs, PhD, DABT, chief scientific officer at Proniras. “Tezampanel holds great potential as a solution to this serious challenge, having shown favorable safety and pharmacokinetic profiles in clinical trials for acute migraine and demonstrating efficacy in preclinical models of nerve agent-induced seizures. Proniras is pleased to have the opportunity to work with BARDA to improve our nation’s health and security preparedness.”

Under the terms of the contract, Proniras will be responsible for conducting preclinical studies, and the clinical development and manufacture of tezampanel. Payments totaling up to $89.5 million can be made upon attainment of pre-specified milestones over a five-year period. Given the inability to assess the safety and efficacy of tezampanel in humans with actual nerve agent exposure, tezampanel will be developed using the U.S. Food and Drug Administration’s (FDA) Animal Rule (21 CFR 314.600). Under this rule, the FDA can accept a New Drug Application for tezampanel based on efficacy data from a pivotal study in animal models of nerve agent-induced seizures and Phase 1 and 2 trials in human subjects with other relevant neurologic conditions, and adequate safety data from trials in healthy human volunteers.

Proniras expects to file an Investigational New Drug application with the FDA to initiate human trials as well as an application for an Orphan Drug designation in 2020 and anticipates receiving an NDA in 2022. The company may also evaluate continuing development of tezampanel in additional commercial indications following its approval as a medical countermeasure.

Tezampanel is a competitive, reversible receptor antagonist that inhibits glutamate signaling through the GluK1 receptor subunit. This is a novel mechanism of action that is distinct from currently approved seizure medications. Recent studies demonstrate that tezampanel is effective in arresting seizures in rodents exposed to the nerve agent, soman.1 Organophosphate nerve agents initiate seizures through cholinergic stimulation, and seizure activity can increase and be propagated by increasing glutamate signaling. While benzodiazepines are currently used for treatment of seizures caused by nerve agents, data show that, with time, seizures can become refractory to benzodiazepines, often returning and worsening in severity after a brief period of suppression. The superior efficacy of tezampanel, compared with benzodiazepines, in rodents exposed to soman may result in part from its direction inhibition of glutamate signaling, which plays a causal role in seizure activity.

“The robust body of human safety data and clinical, manufacturing and control data, coupled with the results of studies in a rodent model of nerve agent-induced seizures, is very compelling and should substantially reduce the development timeline, cost and risk of developing tezampanel as a medical countermeasure,” said David M. Schubert, chief operating officer at Proniras Corporation and chief operating partner at Accelerator Life Science Partners. “BARDA has a demonstrated track record of success in establishing public-private partnerships that support effective development of medical countermeasures. In addition to the funding provided under the contract, we expect that BARDA’s insight and expertise in the health preparedness arena will play a key role in the development of tezampanel.”

About Proniras Corporation
Proniras Corporation is a Seattle-based biopharmaceutical company focused on developing tezampanel as a medical countermeasure for nerve agent-induced seizures. The development of tezampanel in this indication is being funded in whole or in part with federal funds from the U.S. Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority, under Contract No. HHSO100201800008C.

About Accelerator Life Science Partners
Accelerator Life Science Partners catalyzes the development and commercialization of breakthrough biotechnology innovations. Accelerator is a trusted partner that provides the complete business, scientific and financial toolkit necessary for successfully establishing and operating an early-stage biotechnology company. Accelerator nurtures its companies across all stages and in all facets of development, setting them on a path that offers the greatest chance for long-term success. Among these key resources are committed investment capital, experienced start-up management, world-class scientific expertise and state-of-the-art laboratories and shared facilities.

The company is uniquely positioned to provide this unprecedented collection of capabilities and resources through its partnership with top-tier investors, seasoned executive managers and world-class research institutions. The value of these collective resources has been validated over more than a decade of successful investing in life science companies that are helping to shape the rapidly evolving future of medicine and healthcare. For more information, please visit www.acceleratorlsp.com.

1 Apland, JP, Aroniadou-Anderjaska, V, Figueiredo, TH, Green, CE, Swezey, R, Yang, C, Qashu, F, and and Braga, MFM. Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration. JPET 2013: 344-133-140.

 

Media Contacts:

Rathbun Communications
Julie Rathbun
julie@rathbuncomm.com

Accelerator Life Science Partners
Jessica Burback
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T: 206-234-6481


Accelerator Life Science Partners Launches Proniras Corporation to Support Development of Tezampanel in the Treatment of Seizure Disorders

SEATTLE, WA – April 27, 2018 – Accelerator Life Science Partners (Accelerator), a leading life science investment and management firm, today announced that it has launched Proniras Corporation, a company developing tezampanel for the treatment of a variety of seizure disorders. Proniras has licensed exclusive global rights to tezampanel (LY-293,558), a small molecule compound that has been evaluated as a potential therapy for acute migraine in more than 400 patients to date, from Eli Lilly and Company. The launch of Proniras is supported by an initial financing from investors including Alexandria Venture Investments, ARCH Venture Partners, Eli Lilly and Company, Johnson & Johnson Innovation – JJDC, Inc., Watson Fund, L.P., WRF Capital and WuXi AppTec Corporate Ventures.

Recent studies demonstrate that tezampanel effectively arrests seizures in rodents exposed to the nerve agent soman1 and is potentially superior to benzodiazepines, which are the current standard of care for a variety of seizure disorders. Data from previous preclinical studies of tezampanel suggest that the compound elicits its central nervous system effects by antagonizing glutamate signaling.

“Treatment of seizures that result from either physiologic or pharmacologic stimuli is suboptimal for many patients,” said Christopher Toombs, PhD, DABT, co-founder and chief scientific officer at Proniras. “A robust body of clinical and preclinical data supports the potential utility of tezampanel as a novel therapy for seizures and seizure disorders. We believe that tezampanel could address significant unmet need for a safe, effective and durable seizure therapy.”

Dr. Toombs was most recently co-founder and chief scientific officer of Faraday Pharmaceuticals, a Seattle-based biotechnology company. Previously, he held senior leadership positions at Cylerus, Inc., Ikaria, Inc. and Amgen, Inc. Accelerator will manage the company’s executive operations.

“With tezampanel as its lead asset, Proniras is being established with a more advanced product development program than is typical for a start-up biopharmaceutical company,” said Thong Q. Le, chief executive officer at Accelerator. “As a result, we believe that Proniras has substantial near- and mid-term opportunities for value creation in an indication that has not seen significant innovation in many years.”

About Proniras Corporation
Proniras Corporation is a Seattle-based biopharmaceutical company focused on developing tezampanel as a medical countermeasure for nerve agent-induced seizures. The development of tezampanel in this indication is being funded in whole or in part with federal funds from the U.S. Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority, under Contract No. HHSO100201800008C. For more information, please visit www.proniras.com.

About Accelerator Life Science Partners
Accelerator Life Science Partners catalyzes the development and commercialization of breakthrough biotechnology innovations. Accelerator is a trusted partner that provides the complete business, scientific and financial toolkit necessary for successfully establishing and operating an early-stage biotechnology company. Accelerator nurtures its companies across all stages and in all facets of development, setting them on a path that offers the greatest chance for long-term success. Among these key resources are committed investment capital, experienced start-up management, world-class scientific expertise and state-of-the-art laboratories and shared facilities.

The company is uniquely positioned to provide this unprecedented collection of capabilities and resources through its partnership with top-tier investors, seasoned executive managers and world-class research institutions. The value of these collective resources has been validated over more than a decade of successful investing in life science companies that are helping to shape the rapidly evolving future of medicine and healthcare. For more information, please visit www.acceleratorlsp.com.

1 Apland, JP, Aroniadou-Anderjaska, V, Figueiredo, TH, Green, CE, Swezey, R, Yang, C, Qashu, F, and and Braga, MFM. Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration. JPET 2013: 344-133-140.

 

Media Contacts:
Rathbun Communications
Julie Rathbun
julie@rathbuncomm.com

Accelerator Life Science Partners
Jessica Burback
jburback@acceleratorlsp.com
T: 206-234-6481


Accelerator Corporation Announces Key Senior Leadership Appointments and Name Change to Accelerator Life Science Partners

  • Biotechnology industry veterans bring decades of experience in working collaboratively to innovate breakthrough life science products

SEATTLE, Wash. and NEW YORK – December 13, 2017 — Accelerator Corporation a leading life science investment and management firm, today announced the appointments of Kendall Mohler, Ph.D., to the newly created position of chief development officer, and Ian Howes to chief financial officer. The firm also announced that it has changed its name to Accelerator Life Science Partners. The new name reflects Accelerator’s commitment to developing robust, long-term partnerships with its portfolio companies and to nurturing innovation and entrepreneurship within the life science community. This commitment is shared by Accelerator’s current investors, including AbbVie, Alexandria Venture Investments, ARCH Venture Partners, Eli Lilly and Company, Johnson & Johnson Innovation – JJDC, Inc., the Partnership Fund for New York City, Pfizer Venture Investments, Watson Fund, WRF Capital, WuXi AppTec and 180 Degree Capital Corp.

“Innovation takes great ideas, and the translation of ideas into transformative life science products doesn’t occur in a vacuum,” said Thong Q. Le, chief executive officer at Accelerator. “We believe that fostering innovation requires more than providing capital and lab space. It also requires a shared passion for advancing human health and an understanding of how to navigate the complex landscape that such advances often require. The additions of Ken and Ian to our executive team enhances our ability to make that journey — for the benefit of our investors, our portfolio companies and the talented entrepreneurs we work with, and ultimately for patients in need.”

Dr. Mohler has more than two decades of experience in the biopharmaceutical industry, including several years leading scientific research and development teams in the areas of autoimmune disease, inflammation and oncology. He was chief scientific officer and, most recently, senior vice president of research at Juno Therapeutics, Inc. (NASDAQ: JUNO), a clinical-stage cell immunotherapy company focused on re-engaging the body’s immune system to treat cancer. Prior to Juno, Dr. Mohler co-founded Trubion Pharmaceuticals Inc., a biopharmaceutical company focused on the development of novel protein therapeutics to treat autoimmune and inflammatory diseases and cancer. While at Trubion, Dr. Mohler served as the company’s chief scientific officer and senior vice president, and oversaw the development of several first-in-class product candidates and supported several partnerships with global pharmaceutical companies. Dr. Mohler also previously served as vice president of biological sciences at Immunex Corporation, where he played critical roles in the development and approval of Enbrel (etanercept), a multi-billion dollar product for the treatment of several autoimmune diseases. Dr. Mohler has published more than 35 manuscripts and has four issued patents and six pending patent applications. He received a Ph.D. in Immunology from the University of Texas Health Science Center and a B.S. from the University of Kansas.

Mr. Howes has over 20 years of experience in senior financial roles developing early-stage life sciences companies, including the successful completion of numerous rounds of private and public equity and debt transactions and two initial public offerings. He also managed multiple M&A transactions, including the sale of Scioderm to Amicus Therapeutics and the sale of Serenex to Pfizer. Most recently, Mr. Howes served as CFO of Heart Metabolics, a venture-backed pharmaceutical company developing an innovative therapy for the treatment of hypertrophic cardiomyopathy. Previously, he was CFO of Scioderm, a pediatric orphan disease company; CFO for Akebia Therapeutics (NASDAQ: AKBA), a biotechnology company developing pharmaceutical drugs for anemia and ophthalmology; CFO and senior vice president of corporate development at Serenex, an integrated discovery and development oncology company; and CFO and vice president of operations at Paradigm Genetics (NASDAQ: PDGM). Mr. Howes began his professional career with Coopers & Lybrand in London. He is a Chartered Accountant and has an M.B.A. from the Kenan-Flagler Business School at the University of North Carolina at Chapel Hill.

About Accelerator Life Science Partners
Accelerator Life Science Partners catalyzes the development and commercialization of breakthrough biotechnology innovations. Accelerator is a trusted partner that provides the complete business, scientific and financial toolkit necessary for successfully establishing and operating an early-stage biotechnology company. Accelerator nurtures its companies across all stages and in all facets of development, setting them on a path that offers the greatest chance for long-term success. Among these key resources are committed investment capital, experienced start-up management, world-class scientific expertise and state-of-the-art laboratories and shared facilities.

The company is uniquely positioned to provide this unprecedented collection of capabilities and resources through its partnership with top-tier investors, seasoned executive managers and world-class research institutions. The value of these collective resources has been validated over more than a decade of successful investing in life science companies that are helping to shape the rapidly evolving future of medicine and healthcare. For more information, please visit www.acceleratorlsp.com.

 

Media Contacts:

Rathbun Communications
Julie Rathbun
julie@rathbuncomm.com

Accelerator Corporation
Jessica Burback
jburback@acceleratorcorp.com
T: 206-234-6481


Accelerator Corporation Announces Series A Financing in Rodeo Therapeutics to Focus on Small-Molecule Regenerative Therapies

  • Novel Approach to Tissue Repair Holds Promise in Diverse Disease Indications

SEATTLE, WA – July 25, 2017 – Accelerator Corporation, a leading life science investment and management firm, today announced a $5.9 million Series A financing in Rodeo Therapeutics Corporation, a company developing small-molecule therapies designed to promote regeneration and repair of multiple tissue types. Investors participating in the financing include AbbVie Ventures, Alexandria Venture Investments, ARCH Venture Partners, Eli Lilly and Company, Johnson & Johnson Innovation – JJDC, Inc., Watson Fund, L.P., WRF Capital and WuXi AppTec.

“Tissue damage and degradation play critical roles in the development and progression of a broad array of disease indications, including a variety of inflammatory diseases,” said Sanford Markowitz, M.D., Ph.D., the Markowitz-Ingalls Professor of Cancer Genetics and Distinguished University Professor at Case Western Reserve University School of Medicine and a founder of Rodeo Therapeutics. “The ability to stimulate the body’s natural processes for tissue regeneration and repair has broad therapeutic potential in disease settings such as ulcerative colitis and in hemopoietic recovery following bone marrow transplantation. Rodeo Therapeutics is focused on developing small-molecule therapies that stimulate these processes and enable new approaches to address serious medical conditions that today have a substantial unmet medical need.”

“Rodeo Therapeutics’ founding scientists have achieved a level of biology and medicinal chemistry for their lead product candidate that is advanced beyond what we would typically see in an academic setting,” said David M. Schubert, chief operating officer of Accelerator Corporation. “We believe that this Series A investment will provide the financial resources to rapidly advance the company’s development program toward human trials, which will open the door to an exciting new therapeutic approach that has significant clinical and commercial potential.”

Rodeo Therapeutics’ scientific approach is based on research conducted by world-renowned scientists at Case Western Reserve University and the University of Texas Southwestern Medical Center (UT Southwestern). In addition to Dr. Markowitz, the company’s founding scientists are Stanton Gerson, M.D., and Joseph Ready, Ph.D.

  • Dr. Markowitz is an NCI Outstanding Investigator Awardee and principal investigator of the Case GI SPORE, one of five NCI centers awarded nationally for excellence in gastrointestinal cancer research. He has conducted seminal research in the genetic causes of colon cancer and was instrumental in the development of a novel stool DNA test that has won FDA approval for the early detection of colon cancer. His contributions have been recognized with the Hamdan Award for Medical Research Excellence from the government of Dubai and a Top 10 Award from the Clinical Research Forum.
  • Dr. Gerson is director of the Case Comprehensive Cancer Center, the Asa and Patricia Shiverick–Jane Shiverick (Tripp) Professor of Hematological Oncology and founding director of the Ohio Wright Center for Stem Cell and Regenerative Medicine, now called the National Center for Regenerative Medicine. Dr. Gerson has extensive expertise in stem cell research and has led the development of both cell and gene therapies that promote tissue and DNA repair. His research has generated 12 patents in the area of gene therapy and cancer drug development that have been licensed to three companies.
  • Dr. Ready is a professor in the Department of Biochemistry at University of Texas Southwestern Medical Center and the director of the Medicinal Chemistry Laboratory. His research focuses on synthetic and medicinal chemistry in the areas of regenerative medicine, neurodegeneration and oncology. Three previous research projects from his group have been licensed by pharmaceutical companies for further development.

About Rodeo Therapeutics
Rodeo Therapeutics is focused on developing small-molecule therapies that increase tissue levels of prostaglandin PGE2. Preclinical studies published in Science have shown that increasing PGE2 through inhibition of a prostaglandin-degrading enzyme (15-PGDH) accelerates hematopoietic stem cell reconstitution following bone marrow transplant, protects against colitis and promotes liver regeneration in a variety of animal models.1 The company will initially focus on developing 15-PGDH inhibitors for the treatment of inflammatory bowel disease and promoting blood cell reconstitution following bone marrow transplant.

1 Zhang Y et al. Science. 2015;348(6240):aaa2340. doi: 10.1126/science.aaa2340